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Our findings regarding combination therapy contrast with those of earlier trials involving patients with heart failure in which the addition of an ARB to an ACE inhibitor was of some benefit.

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Other missing results for 24-h BP measurements, clinical chemical analyses, or nocturnal monitoring of ventilation (numbers of valid measurements specified in Tables ) had technical explanations not linked to specific treatments.

Despite those impressive results, the clinical application of this novel agent that requires the substitution of a cornerstone of current heart failure therapy, the angiotensin-converting enzyme inhibitors, should follow careful steps as imposed by the study design, the recruited population and the outcome in specific patient subgroups.

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