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It's no fun, but clean yourself out with at least one full bag enema first, wait and hour and then put it in. This always works for me. I hope it helps.

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It takes my colitis pain away and aids me in decreasing my flare ups but the side effects are lower back pain and tiredness. I only use when I have to.

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As for counterfeit medication, mentioned by Dave- it hasn't been a giant downside within the US and Canada. It is extra of a problem in third world countries, but when we hold reducing the budgets for our regulatory businesses, we may get to that time some day.
Does Large Pharma get to write down off the ninety p.c of these expenditures that end with out approval to sell the drug? I don't know, but even if they do, that just means they don't pay taxes on the money they pay out when a drug candidate fails to get NDA. Most of that money continues to be misplaced capital and it runs into the billions. And if AOC desires a slice of Huge Pharma earnings for Congress, she should logically advocate for Congress to kick in for a part of the drug improvement course of' costs, that are massively greater than what NIH pays for research that research illness processes to establish targetable proteins and receptors.
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