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Boggs J, Reed RC ( 2006) Clinical intoxication and breakthrough seizures resulting from substitution of enteric-coated divalproex for once-daily extended-release divalproex, 1st North American Regional Epilepsy Congress, an Annual Meeting of the American Epilepsy Society (AES), and the Canadian League Against Epilepsy, San Diego, CA.
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The data described in the following section were obtained using Depakote (divalproex sodium) tablets.
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The speed and duration of withdrawal of the concomitant AED can be highly variable, and patients should be monitored closely during this period for increased seizure frequency.
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In epileptics, divalproex is used to control absence seizures, tonic-clonic seizures (grand mal), complex partial seizures, and the seizures associated with Lennox-Gastaut syndrome.
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For individuals with epilepsy, adherence to medication is crucial in preventing or minimizing seizures and their cumulative impact on everyday life.
Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
The use of intravenous valproate in acute mania: General Hospital Psychiatry Vol 22(5) Sep-Oct 2000, 389-391.
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However, further research in older children and adults is needed.
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Gomes and Maia (1988) used questionnaires to ask individuals with epilepsy a number of questions related to medication-taking and reported that 61.
In elderly patients, dosage adjustment and close monitoring of potential side effects will be important.
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Effects of sodium valproate and carbamazepine on food competition aggression in pigeons: Brazilian Journal of Medical and Biological Research Vol 40(6) Jun 2007, 849-855.
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This older group of patients should be closely monitored during treatment with Depakene for the development of acute liver injury with regular clinical assessments and serum liver testing.
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Alcohol withdrawal syndrome: Guidelines for management: CNS Drugs Vol 12(4) Oct 1999, 279-291.
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Do not stop using this medicine suddenly.
As mentioned previously, blood level monitoring shows recent doses taken prior to attending the clinic, but a patient may have been omitting many doses previously without this being apparent ().
Is your doctor monitoring your liver enzymes because of the Depakine?
Always consult your doctor before taking these medications together.
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Tegretol has a possible adverse reaction of causing hyponatremia, which means there is a decrease in the amount of salt in the body fluids.
They need to be replicated in a larger study group.
Tiagabine selectively increases synaptic GABA availability by blocking the reuptake of GABA via transporter inhibition.
All this has already been accomplished by the original manufacturer, and was subsequently reflected in the brand-name drug price.
Early intervention for the ocular and neurodevelopmental sequelae of fetal valproate syndrome: Journal of Paediatrics and Child Health Vol 43(9) Sep 2007, 643-645.
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Aldenkamp AP, Alpherts WCJ, Moerland MC, Ottevanger N, Parys JAP ( 1987) Controlled-release carbamazepine: cognitive side effects in patients with epilepsy.
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Bareggi SR, Tata MR, Guizzaro A, Pirola R, Parisi A, Monza CG ( 1994) Daily fluctuation of plasma levels with conventional and controlled-release carbamazepine: correlation with side effects.
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Teenagers with epilepsy appear to adhere less to medication.
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